Depends on the product development goals. For new ingredient development, most teams start with Discovery Flywheel™ to quickly identify signals for efficacy claims, then add BioSēq™ on the most promising conditions to validate mechanisms and strengthen claims. Sometimes, the ingredient is already validated clinically, and BioSēq™ can be used to uncover MoA and generate new insights and directions for product positioning. We recommend both for robust mapping of in vivo biology of your ingredients, strengthening your intellectual property, and de-risking clinical studies.

The six health benefits included in the Discovery Flywheel™ provide claim signals for longevity, muscle health, cognitive performance, metabolic health, stress resilience and gut health. You have the option of choosing one or more health benefits to run your ingredient discovery program. Choosing only one health benefit significantly increases the risk of not finding a positive claim signal. That’s why NemaLife developed the Discovery Flywheel™ , and our experience is that natural bioactive ingredients often target not just one but multiple benefits!

Yes. All discovery programs involve a formulation assessment, where the solubility and pH of the ingredient in the nematode growth media are evaluated. In addition, an acute toxicity study is conducted at the highest soluble dose to ensure the Discovery Flywheel™ and BioSēq™ studies run smoothly.

NemaLife has developed a proprietary means to convert human doses to C. elegans doses that takes into account the immersive fluid environment in the microfluidic chips. Traditional C. elegans studies done on agar plates, suffer from estimating compound exposure to worms, since the compound gets into the agar medium which may not be accessible to the worms. We solved this problem using microfluidics and found that our proprietary conversion of doses reported for clinically-validated ingredients shows efficacy in C. elegans.

For discovery programs that involve a well-defined number of study arms and benefit end points, we have a standard pricing structure as part of our services. We also work with customers on specific ingredient solutions (e.g. bioactive combinations for specific benefits) that require iterative discovery and validation work. In this case, we structure our engagement based on upfront and milestone payments.

The turnaround time for data delivery can be as little as 10 weeks to 16 weeks depending on the project scope and readouts. We align timeline expectations during scoping.

Yes. Many of our partners have used bio-Intelligence data to identify new indications and efficacy claims to secure intellectual property on the ingredients - all in few months.