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NemaLife News

  • Writer's pictureLevi Glover

June 2024 Industry News

Smart Worms for the Discovery of Smart Bioactives


In today's fast-paced world, cognitive health has emerged as a critical pillar of overall well-being. As we navigate the complexities of modern life, maintaining a sharp and agile mind is essential not only for personal success but also for a fulfilling and enriched life. Cognitive health impacts our ability to think, learn, remember, and manage stress, forming the foundation of our daily functioning. Prioritizing cognitive health can enhance productivity, emotional regulation, and overall quality of life. Our latest blog, "Smart Worms for Discovery of Smart Bioactives," dives into the importance of cognitive health and how nutritional bioactives from functional foods can support and enhance brain function. From combating oxidative stress to regulating neurotransmitter activity, these powerful nutrients offer a natural way to keep our minds sharp and agile. Read More 


Natural Estrogen Support: Probiotic Formula Enhances Hormone Balance in Menopausal Women


The research investigates gut microbiota's role in regulating estrogen levels in menopausal women. Declining estrogen during menopause can lead to symptoms impacting quality of life. The study highlights β-glucuronidase, a microbial enzyme that reactivates estrogen glucuronides, allowing estrogens to re-enter the bloodstream. Researchers identified strains of Levilactobacillus brevis and Lacticasebacillus rhamnosus with deconjugating capabilities, with L. brevis KABP052 showing the highest activity. In a randomized, placebo-controlled trial, women given a probiotic formula with KABP052 maintained stable estrogen levels, unlike the placebo group, which saw declines. This study is the first to show that probiotics with β-glucuronidase-active bacteria can modulate estrogen levels during menopause, suggesting potential for future interventions. Read More 


Unlocking the Secrets of Aging: Gene-Regulatory Networks Revealed with Innovative Techniques


This research investigates why people age differently and how these differences in lifespan can't be entirely explained by genetics or environmental factors. The study introduces Asynch-seq, a new method that analyzes variations in gene expression within identical populations. By studying Caenorhabditis elegans, researchers created a comprehensive "pan-transcriptome" map that details non-genetic variations. This map revealed that differences in mRNA content between reproductive (germline) and somatic cells are a significant source of aging-related physiological differences. Further experiments showed that targeting specific genes involved in these processes can significantly reduce the variation in lifespan. These findings underscore the importance of non-genetic factors in aging and suggest that focusing on these factors can lead to better understanding and management of aging processes.  Read More 


Unlocking the Hidden Dangers: How Glucose-Fed Microbiota Weakens C. elegans Intestinal Defense Against Pathogens


Overconsumption of dietary sugar is linked to health issues like Type 2 diabetes, metabolic syndrome, cardiovascular disease, and neurodegenerative disorders. This study uses a C. elegans/E. coli model to explore how chronic sugar intake affects the microbiota and host health. E. coli exposed to high sugar were consumed by C. elegans, leading to a microbiota that significantly reduced lifespan, healthspan, stress resistance, and altered behavior. Increased intestinal bacterial density and reactive oxygen species were observed. The glucose-fed microbiota accelerated age-related intestinal issues and immune dysregulation, increasing susceptibility to bacterial pathogens. These findings suggest that a high-sugar diet profoundly impacts health by altering the microbiota, contributing to inflammatory bowel diseases and age-related ailments. Read More 


Blooming Botanicals: Captivating Trends in Botanical Ingredients


The demand for vegan, plant-based, clean label, and functional products is driving the popularity of botanical ingredients from various plant parts. Lu Ann Williams from Innova Market Insights notes the rise in active mushrooms, adaptogenic plants, and algal ingredients. Valued at $164.4 billion, the global botanical ingredients market is projected to grow at a 6.9% CAGR from 2023 to 2030, led by North America. Familiar botanicals like ginger, chamomile, ginseng, and turmeric are highly recognized by consumers. Spices lead the segment, but flower ingredients are expected to grow the fastest, particularly in ready-to-drink functional beverages. Ayurvedic herbs like ashwagandha and active mushrooms like lion’s mane, reishi, and chaga are gaining popularity for their health benefits. These trends show a shift towards botanical ingredients in food and beverages to meet the growing demand for healthier options. Read More 


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