PUBLICATIONS
Food-derived terpenoids such as thymol and carvacrol activate cellular recycling pathways linked to healthy aging by modulating mitochondrial function. These findings support their potential as science-backed ingredients for promoting metabolic health and healthspan.
Targeted delivery of hydrogen sulfide to mitochondria improves healthspan by preserving mitochondrial integrity and neuromuscular function, even when administered during adulthood.
Tart cherry extract supplementation enhances healthspan by improving mitochondrial function and reducing oxidative stress through activation of the DAF-16/FOXO longevity pathway.
This study explores the role of the microRNA miR-361-5p in cellular senescence and aging, showing that while increasing miR-361-5p can reduce senescence markers in human endothelial cells, manipulating its conserved targets in a C. elegans model negatively affected healthspan and/or lifespan.
This study presents a compact, USB-powered imaging platform that enables whole-organism C. elegans phenotypic assays on Earth and in space without bulky optics, simplifying behavioral and locomotion measurements.
The reverse transcriptase inhibitor 3TC improves age-related cognitive function and reduces neuroinflammation in older mice, while also preserving neuronal health in both mice and C. elegans, supporting the idea that accumulated transposable element transcripts contribute to brain aging and cognitive decline.
This study reports microfluidics-integrated spaceflight hardware developed to measure muscle strength in Caenorhabditis elegans across multiple generations on the International Space Station, addressing unique challenges of space biology experimentation.
Long-term, physiologically relevant exposure to cannabidiol (CBD) in C. elegans showed no acute toxicity, enhanced heat stress resistance, increased late-life activity, and modest lifespan extension at optimal doses.
This study developed a movement-based biological age predictor, “MoveAge,” using wearable accelerometer data and machine learning to estimate healthy aging in people and link it to mortality risk.
This open-access review highlights how Caenorhabditis elegans is used to evaluate the healthy aging effects of FDA-approved drugs, showing that compounds like alogliptin, canagliflozin, and metformin can extend lifespan and/or healthspan in the worm model.
This Proceedings of the National Academy of Sciences study shows that mitochondria-targeted hydrogen sulfide (mtH₂S) supplementation preserves mitochondrial health, neuromuscular function, and overall healthspan in C. elegans, with benefits even when treatment begins in adulthood.
A senotherapeutic peptide identified through a multi-step screen reduces cellular senescence and biological age in human skin models and, when tested in C. elegans, extends lifespan and improves healthspan without toxicity, underscoring its potential as a geroprotective compound.
This study describes the NemaLife chip, a micropillar-based microfluidic device optimized for the whole-life culture and crawling behavior of Caenorhabditis elegans, enabling reliable measurement of survival and healthspan metrics without manual transfers.
This study reveals that a central interkinase region of the giant muscle protein UNC-89 (obscurin) in C. elegans behaves as a highly elastic spring critical for proper sarcomere organization and muscle function.
This open-access article uses Caenorhabditis elegans to investigate conserved biological mechanisms with relevance to aging and physiology, illustrating how insights from this model organism can illuminate fundamental processes that are often shared across species.
This study uses a microfluidic force measurement system (NemaFlex) to show that dystrophin-deficient Caenorhabditis elegans mutants exhibit reduced muscle strength, altered locomotion, and mitochondrial dysfunction
This study introduces NemaFlex, a microfluidic system that measures C. elegans muscle strength by quantifying deflection as worms crawl through an array of micropillars, providing standardized, behavior-independent force readouts.