Nourishing Muscles: The Quest for Novel Bioactives to Improve Muscle Health
Discover the frontier of muscle health with our latest blog, where we delve into the remarkable potential of C. elegans in bioactive discovery. Learn how NemaLife's innovative platform is revolutionizing the identification of novel bioactives for diverse consumer needs. Join us in shaping the future of functional ingredients. Read More.
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia
A team led by Nestle Research reveals a vital link between trigonelline, NAD+ levels, and muscle health. Trigonelline is naturally present in coffee and fenugreek. Lower trigonelline levels are associated with sarcopenia in humans, while trigonelline supplementation boosts NAD+ levels, improves muscle function, and extends lifespan in multiple models. Trigonelline enhances mitochondrial function and prevents muscle wasting through an NAD+-dependent mechanism, offering a promising approach to combat age-related muscle decline. Read More.
Bisphosphonates attenuate age-related muscle decline in Caenorhabditis elegans
Recent research suggests bisphosphonates may promote muscle health, but their effectiveness remains uncertain. Researchers at the Exeter University, used NemaLife's organism-on-chip technology and Caenorhabditis elegans as a model to examine zoledronic acid (ZA), a bisphosphonate's effects on lifespan and healthspan. Findings reveal lower ZA concentrations extend lifespan and healthspan, while higher doses prove lethal. ZA enhances muscle structure and mitochondrial network, pinpointing key genes in its mechanism. Read More.
Bifidobacterium animalis subsp. lactis BPL1™ and Its Lipoteichoic Acid Modulate Longevity and Improve Age/Stress-Related Behaviors in Caenorhabditis elegans
As people live longer, maintaining elderly health is vital. In this study, scientists at ADM explore how Bifidobacterium animalis subsp. lactis BPL1™ affect longevity and health in Caenorhabditis elegans (C. elegans). Results show that BPL1™, its heat-treated form (BPL1™ HT), and its metabolite lipoteichoic acid (LTA) extend lifespan through the insulin/IGF-1 pathway. They also improve oxidative stress response, gut health, infection resistance, stress-related behaviors, and combat Alzheimer's proteotoxicity. Read More.
Assessment of stability and bioactive compounds in yogurt containing novel natural starter cultures with the ability to promote longevity in Caenorhabditis elegans
This study explores the probiotic benefits of specific yogurt strains using Caenorhabditis elegans as a model. The strains, S. thermophilus BGKMJ1-36 and L. bulgaricus BGVLJ1-21, were found to enhance autophagy-related genes and activate antimicrobial genes, improving immune defense in the worms. Additionally, yogurt made with these strains was rich in vitamin B2 and amino acids associated with longevity. These findings suggest the potential for yogurt as a beneficial fermented food. Read More.